25 Cadre of Death is an action-horror adventure game with a first-person view. The main character, Caleb Reedus, watches the evening news after a hard day at work, and nothing would have foreshadowed trouble if the news had not suddenly interrupted, showing the broadcast of some strange video. Without paying much attention to this, Caleb goes to bed, dismissing what is happening as a bad dream. Waking up, Caleb realizes with horror that he is not at home.