Ben 10: Omniverse is a multiplayer game similar to Ben 10: Protector of Earth and Ben 10: Alien Force. Player 1 takes on the role of Ben Tennyson, who alternates between his teenage and younger versions, and Player 2 takes on the role of Rook Blonko, Ben's partner. Players as Ben can access 13 of his alien forms, but they can only transform into 4 of them, where they can change this each time, while players as Rook are equipped with a Proto-Tool that transforms into different weapons that can be use in battle. They must solve a variety of puzzles and defeat waves of enemies with appropriate abilities to continue advancing through the levels. Players can also interact with certain items, which can be opened or dragged.