Darkspore, a genetically mutated army, was created by the Crogenites, a race unmatched in intelligence. However, Darkspore soon escaped the control of its creators. A distinctive feature of Darkspore is the presence of E-DNA, a substance that can cause entire planets to mutate. The player is a fugitive in hiding, Krogenite, who is given the mission to collect and improve various genetically mutated heroes from different parts of the galaxy with one goal — using their unique abilities to prevent Darkspore from seizing control of the galaxy.