Gene Rain is an action-adventure game with a third-person view in a sci-fi setting. The war that began 15 years ago has killed 1.9 million people and devastated the world so much that survivors can only live if their hearts are replaced with mechanical ones. But one of the factions — Eagle Eye — is hostile towards people, having seized most of the resources. The girl, who tells all this against the backdrop of firefights and footage of the war, calls for restoring power and recapturing those who captured Eagle Eye, despite the fact that they are superior in strength and numbers.