The game takes place after the events at the Wildberger Clinic shown in the first part. The younger sister of the main character, Caroline, was struck by a mysterious illness — she began to cough up blood and lose her creature. Since the doctors are powerless, the girl decided to seek help from supernatural forces and went to the secluded town of Puerto Milleya, which was founded by a religious community.
As she progresses, Carolina explores the corridors of ominous monasteries and other creepy places, fighting monstrous creatures with the help of improvised means and homemade weapons, and also solves sophisticated puzzles.