Uncharted is a series of action-adventure games in the style of Tomb Raider, the main character of which is treasure hunter and adventurer Nathan Drake. He is the protagonist throughout the series and is beloved by fans for his charismatic personality, sense of humor and, of course, desire to constantly get into trouble during his travels. Roughly speaking, this is the male version of Lara Croft.
There is also a game in the series in which Nathan Drake leaves the main role. It's called Uncharted: The Lost Legacy. Instead of Nathan, the protagonists are two girls who go to India to get the “Tusk of Ganesha” artifact.