They Always Run is a side-scrolling action-adventure platformer set in a sci-fi setting. The main character in the game is a character named Aiden. He is a mutant with three arms who hunts the heads of the most dangerous criminals in the Galaxy. According to the plot, the hero will be drawn into a “conspiracy of galactic proportions.” The character can use the third hand to interact with the environment, throws and perform targeted attacks. In the game you can upgrade your equipment and learn new abilities. The developers also highlight unexpected twists in the narrative.